VIP - 10mg
VIP - 10mg - Image 2

VIP – 10mg

$79.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

VIP (Vasoactive Intestinal Peptide)

Research-Grade Neuropeptide Hormone
Tagline: Neuroendocrine & Immune Modulation Research

Product Description

Vasoactive Intestinal Peptide (VIP) is a 28–amino acid neuropeptide that acts as a potent vasodilator, neurotransmitter, and immune regulator. It is produced in the central and peripheral nervous system and is involved in regulating smooth muscle relaxation, circadian rhythms, immune tolerance, and endocrine secretion.

Researchers use VIP in preclinical studies to explore neuroprotection, gastrointestinal motility, immunoregulation, and inflammatory disease models. VIP is also of interest in autoimmune and neurodegenerative research due to its anti-inflammatory and neurotrophic effects.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose VIP

  • Potent Vasodilator: Useful in vascular tone and blood flow research.

  • Anti-Inflammatory Properties: Downregulates pro-inflammatory cytokine production.

  • Neuroprotective Effects: Supports studies of neuronal survival and neurodegeneration.

  • Circadian Rhythm Research: Critical for suprachiasmatic nucleus (SCN) function and clock gene regulation.

  • Batch Verified: ≥98% purity, tested by HPLC and mass spectrometry.

Research Data & Handling Tips

  • Reconstitution: Dissolve lyophilized peptide in sterile water or PBS; mix gently.

  • Solubility: Fully soluble in water, slightly soluble in alcohol.

  • Storage: Store lyophilized peptide at -20 °C; after reconstitution, aliquot and keep at -80 °C.

  • Stability: Stable for 24 months (lyophilized); use within 4–8 weeks after reconstitution.

Important Note

For laboratory and scientific research only. Not for human consumption, therapeutic, or diagnostic use.

Details

Chemical Formula C₁₄₇H₂₃₈N₄₄O₄₃S
Molecular Mass ~3325.9 Da
CAS Number 40077-57-4
Vial Size 1 mg, 5 mg, 10 mg
Form Lyophilized peptide powder
Solubility Water, PBS, dilute acid
Shelf Life 24 months (lyophilized)
Handling Protect from light; avoid repeated freeze-thaw cycles
Intended Use For preclinical and in vitro research only
Storage -20 °C (dry powder), -80 °C (after reconstitution)

Research

Research Applications

Vasodilation & Cardiovascular Studies

VIP induces smooth muscle relaxation and vasodilation, making it key for vascular tone and blood pressure research [1].

Immune Regulation & Autoimmunity

Demonstrated to shift immune responses toward a Th2 profile, suppressing pro-inflammatory Th1/Th17 pathways [2].

Neuroprotection & CNS Research

Shown to protect neurons from excitotoxicity and oxidative damage in neurodegenerative models [3].

Circadian Rhythm & Sleep Research

VIP is essential for synchronization of SCN neurons and circadian rhythm maintenance [4].

References

  1. Said SI et al. (1970). Discovery of Vasoactive Intestinal Peptide and Vasodilation Effects. Science.
    https://www.scirp.org/reference/referencespapers?referenceid=220697

  2. Delgado M et al. (2004). VIP and Immune Tolerance in Autoimmune Models. Nat Rev Immunol.
    https://digital.csic.es/bitstream/10261/9350/1/Pozo_Delgado_FASEB_Journal_2004.pdf

  3. Brenneman DE et al. (1998). Neurotrophic Effects of VIP in CNS Cultures. J Neurosci Res.
    https://www.sciencedirect.com/science/article/pii/B9780123694423501951

  4. Harmar AJ et al. (2002). VIP Receptors and Circadian Clock Synchronization. Neuron.
    https://www.cell.com/fulltext/S0092-8674%2802%2900736-5

Mechanism of Action

Mechanism of Action (How VIP Works)

  • VPAC Receptor Activation: Binds VPAC1 and VPAC2 receptors, activating adenylate cyclase and increasing cAMP [Said 1970].

  • Smooth Muscle Relaxation: cAMP signaling leads to PKA activation and smooth muscle relaxation [Said 1970].

  • Immunomodulation: Shifts cytokine profile toward anti-inflammatory IL-10 production while suppressing TNF-α and IL-12 [Delgado 2004].

  • Neuroprotection: Enhances neuronal survival by activating anti-apoptotic and neurotrophic pathways [Brenneman 1998].

  • Circadian Rhythm Control: Synchronizes SCN neuronal firing and clock gene expression [Harmar 2002].

References

  1. Said SI et al. (1970). Discovery of Vasoactive Intestinal Peptide and Vasodilation Effects. Science.
    https://www.scirp.org/reference/referencespapers?referenceid=220697

  2. Delgado M et al. (2004). VIP and Immune Tolerance in Autoimmune Models. Nat Rev Immunol.
    https://digital.csic.es/bitstream/10261/9350/1/Pozo_Delgado_FASEB_Journal_2004.pdf

  3. Brenneman DE et al. (1998). Neurotrophic Effects of VIP in CNS Cultures. J Neurosci Res.
    https://www.sciencedirect.com/science/article/pii/B9780123694423501951

  4. Harmar AJ et al. (2002). VIP Receptors and Circadian Clock Synchronization. Neuron.
    https://www.cell.com/fulltext/S0092-8674%2802%2900736-5

Certificate of Authenticity

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