PT-141 Spray 10mg

PT-141 Spray 10mg

$45.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

Our Spray Kits Come unassembled. They include
– PT-141 10mg Vial
– 3ML Luer Lock Syringe
– Spray Bottle
– 10ML Bacteriostatic Water

Only 10 left in stock

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Description

PT-141 Spray (10 mg)

Research-Grade Melanocortin Receptor Agonist
Tagline: Neuroendocrine & Vascular Response Research

Product Description

PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist derived from the peptide Melanotan II. It is a potent activator of the MC3R and MC4R receptors in the central nervous system, which regulate sexual arousal, vascular tone, and neuroendocrine signaling.

The nasal spray formulation offers a non-invasive route for studying central melanocortin receptor activation, allowing researchers to investigate PT-141’s effects on neurovascular modulation, libido-related pathways, and metabolic signaling.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose PT-141 Nasal Spray

  • CNS-Targeted Melanocortin Research: Acts on MC3R/MC4R in hypothalamic and limbic regions.

  • Vascular & Endothelial Function Models: Stimulates nitric oxide pathways and vasodilation.

  • Behavioral Neuroscience Research: Used in studies of arousal, reward, and mood regulation.

  • Rapid Absorption: Intranasal delivery provides direct CNS exposure.

  • High Purity: ≥98 % purity confirmed by HPLC and mass spectrometry.

Research Data & Handling Tips

  • Formulation: Pre-formulated 10 mg peptide in isotonic saline nasal spray solution.

  • Solubility: Water, saline, or PBS.

  • Storage: Store refrigerated (2–8 °C), protect from light.

  • Stability: Stable for 12 months refrigerated; do not freeze.

  • Handling: Shake gently before use; handle aseptically.

Important Note

For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.

Details

Formulation Type Pre-formulated nasal spray solution
Peptide Content 10 mg PT-141 per vial
Chemical Formula C50H68N14O10
Molecular Mass ~1025.2 Da
Appearance Clear, colorless aqueous solution
Intended Research Use Neuroendocrine, vascular, and behavioral pathway studies
Storage Conditions Refrigerated (2–8 °C), protect from light
Handling Do not freeze; handle aseptically
Vial Size 10 mL

Research

Research Applications

Neuroendocrine and Sexual Function Studies

PT-141 activates melanocortin 3 and 4 receptors (MC3R/MC4R) within the hypothalamus, influencing sexual behavior and arousal independent of peripheral nitric-oxide donors. Preclinical studies in rats and humans showed enhanced libido and erectile responses [Wessells 2000].

Vascular Regulation and Hemodynamics

Research indicates PT-141 induces vasodilation via central melanocortin pathways, increasing perfusion in target tissues through sympathetic and parasympathetic modulation [Diamond 2004].

CNS Signaling and Behavioral Research

As a melanocortin agonist, PT-141 affects reward, motivation, and mood pathways in the limbic system, offering value in neuromodulation and neuroendocrine response studies [Shadiack 2002].

Metabolic and Energy Balance Models

MC4R signaling is linked to energy expenditure and feeding behavior. PT-141’s receptor activity provides a framework for studying appetite suppression and weight regulation mechanisms [Cone 2005].

References

  1. Wessells H, et al. (2000). Melanocortin receptor agonists and erectile physiology: role of MC4R activation. J Urology.
    https://pubmed.ncbi.nlm.nih.gov/11025701/

  2. Diamond LE, et al. (2004). Bremelanotide for treatment of sexual arousal disorders: CNS mechanisms and clinical findings. J Sex Med.
    https://pubmed.ncbi.nlm.nih.gov/16409230/

  3. Shadiack AM, et al. (2002). Melanocortin receptor activation in the CNS modulates sexual behavior and motivation. Pharmacology Biochemistry and Behavior.
    https://pubmed.ncbi.nlm.nih.gov/11812510/

  4. Cone RD (2005). Anatomy and regulation of the central melanocortin system. Nature Neuroscience.
    https://www.nature.com/articles/nn1455

Mechanism of Action

Mechanism of Action (How PT-141 Works)

  • MC3R/MC4R Agonism: Binds to central melanocortin receptors in hypothalamic regions, influencing arousal and energy homeostasis [Wessells 2000].

  • Neurovascular Activation: Stimulates CNS pathways that enhance parasympathetic outflow and nitric-oxide-mediated vasodilation [Diamond 2004].

  • CNS Penetration via Nasal Route: Intranasal delivery enables direct olfactory transport to CNS tissues [Diamond 2004].

  • Neuroendocrine Modulation: Increases dopamine and oxytocin signaling associated with motivation and pleasure [Shadiack 2002].

  • Energy & Appetite Regulation: Modulates leptin–melanocortin feedback loops influencing feeding and metabolic rate [Cone 2005].

References

  1. Wessells H, et al. (2000). Melanocortin receptor agonists and erectile physiology: role of MC4R activation. J Urology.
    https://pubmed.ncbi.nlm.nih.gov/11025701/

  2. Diamond LE, et al. (2004). Bremelanotide for treatment of sexual arousal disorders: CNS mechanisms and clinical findings. J Sex Med.
    https://pubmed.ncbi.nlm.nih.gov/16409230/

  3. Shadiack AM, et al. (2002). Melanocortin receptor activation in the CNS modulates sexual behavior and motivation. Pharmacology Biochemistry and Behavior.
    https://pubmed.ncbi.nlm.nih.gov/11812510/

  4. Cone RD (2005). Anatomy and regulation of the central melanocortin system. Nature Neuroscience.
    https://www.nature.com/articles/nn1455

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