Thymosin Alpha-1 - 5mg
Thymosin Alpha-1 - 5mg - Image 2

Thymosin Alpha-1 – 5mg

$35.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

Thymosin Alpha-1 (Tα1)

Research-Grade Immunomodulatory Peptide
Tagline: Immune System & Inflammation Research

Product Description

Thymosin Alpha-1 (Tα1) is a 28–amino acid peptide fragment derived from the thymic hormone prothymosin alpha. It is a potent immunomodulatory molecule that enhances both innate and adaptive immune responses.

Researchers use Tα1 in preclinical and in vitro studies to explore immune activation, T-cell function, antiviral defense, and tumor immunology. It is widely studied for its potential to regulate immune tolerance, modulate cytokine production, and restore immune balance in immune-suppressed states.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose Thymosin Alpha-1

  • Immune Activation: Enhances T-cell differentiation and NK cell activity.

  • Broad Research Relevance: Studied in infection, cancer immunology, and vaccine adjuvant research.

  • Cytokine Modulation: Promotes Th1 response, increases IFN-γ production.

  • Well-Characterized Peptide: Clinically investigated, with decades of published data.

  • Batch Verified: ≥98% purity, identity confirmed by HPLC and mass spectrometry.

Research Data & Handling Tips

  • Reconstitution: Reconstitute lyophilized peptide with sterile water or PBS.

  • Solubility: Fully soluble in water and most physiological buffers.

  • Storage: Store lyophilized peptide at -20 °C. After reconstitution, aliquot and freeze at -80 °C.

  • Stability: Stable for 24 months (lyophilized); use within 4–8 weeks after reconstitution.

Important Note

For laboratory and scientific research only. Not for human consumption, therapeutic, or diagnostic use.

Details

Chemical Formula C₁₂₉H₂₁₅N₃₃O₅₅
Molecular Mass ~3108.3 Da
CAS Number 62304-98-7
Vial Size 1 mg, 5 mg, 10 mg
Form Lyophilized peptide powder
Solubility Water, PBS, cell culture media
Shelf Life 24 months (lyophilized)
Handling Protect from light; avoid repeated freeze-thaw cycles
Intended Use For preclinical and in vitro research only
Storage -20 °C (dry powder), -80 °C (after reconstitution)

Research

Research Applications

Immune System Stimulation

Tα1 enhances T-cell differentiation, dendritic cell maturation, and NK cell cytotoxicity in immune models [1].

Infectious Disease & Antiviral Research

Shown to boost immune response to viral infections, increasing IFN-α and IL-2 production [2].

Cancer Immunology

Investigated as an immune adjuvant to increase tumor antigen presentation and cytotoxic T-cell response [3].

Autoimmune & Immune Tolerance Studies

Reported to modulate regulatory T-cell activity, restoring immune balance in autoimmune models [4].

References

  1. Goldstein AL et al. (1981). Thymosin Alpha-1: Chemistry and Biological Activity. Ann N Y Acad Sci.
    https://www.sciencedirect.com/science/article/pii/S0196978110003384

  2. Wang FS et al. (2004). Thymosin Alpha-1 Enhances Antiviral Immunity in Chronic Infection Models. J Hepatol.
    https://europepmc.org/article/MED/15546254

  3. Garaci E et al. (2000). Role of Thymosin Alpha-1 in Tumor Immunology. Cancer Immunol Immunother.
    https://www.sciencedirect.com/science/article/pii/S0192056100000758

  4. Romani L et al. (2006). Thymosin Alpha-1 and Immune Regulation in Autoimmunity. Ann N Y Acad Sci.
    https://europepmc.org/article/MED/17495242

Mechanism of Action

Mechanism of Action (How Thymosin Alpha-1 Works)

  • TLR Pathway Activation: Binds to Toll-like receptors (TLR2, TLR9) on dendritic cells and macrophages, triggering innate immune activation [Goldstein 1981].

  • Th1 Immune Shift: Promotes IL-2 and IFN-γ production, enhancing cell-mediated immunity [Wang 2004].

  • Cytotoxic T-Cell Support: Increases expression of MHC class I/II molecules, improving antigen presentation [Garaci 2000].

  • NK Cell Potentiation: Boosts natural killer cell cytotoxicity and anti-viral response [Wang 2004].

  • Immune Homeostasis: Modulates Treg and Th17 balance, helping restore immune tolerance [Romani 2006].

References

  1. Goldstein AL et al. (1981). Thymosin Alpha-1: Chemistry and Biological Activity. Ann N Y Acad Sci.
    https://www.sciencedirect.com/science/article/pii/S0196978110003384

  2. Wang FS et al. (2004). Thymosin Alpha-1 Enhances Antiviral Immunity in Chronic Infection Models. J Hepatol.
    https://europepmc.org/article/MED/15546254

  3. Garaci E et al. (2000). Role of Thymosin Alpha-1 in Tumor Immunology. Cancer Immunol Immunother.
    https://www.sciencedirect.com/science/article/pii/S0192056100000758

  4. Romani L et al. (2006). Thymosin Alpha-1 and Immune Regulation in Autoimmunity. Ann N Y Acad Sci.
    https://europepmc.org/article/MED/17495242

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