Semax Spray 10mg

Semax Spray 10mg

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

Categories: ,

Description

Semax Spray (10mg)

Research-Grade Heptapeptide Neuroprotective Formula
Tagline: Cognitive & Neuroregenerative Research

Product Description

Semax is a synthetic heptapeptide analogue of adrenocorticotropic hormone (ACTH 4–10) designed for research on cognitive enhancement, neuroprotection, and neuroplasticity. It has been extensively studied in neurological, ischemic, and cognitive impairment models for its ability to modulate neurotrophin expression, oxidative stress response, and neurotransmitter balance.

The nasal spray formulation allows researchers to explore non-invasive CNS peptide delivery, bypassing systemic degradation and enabling direct brain-targeted investigations via the olfactory pathway.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose Semax Nasal Spray

  • Neuroprotective & Nootropic Model: Enhances BDNF, NGF, and synaptic signaling in brain tissue studies.

  • Ischemic Injury Research: Shown to improve neuronal survival and cognitive function post-hypoxia.

  • Intranasal CNS Delivery: Provides efficient peptide absorption to the brain.

  • Stress & Neuroinflammation Studies: Reduces oxidative and inflammatory stress responses.

  • High Purity: ≥98% purity confirmed via HPLC and MS analysis.

Research Data & Handling Tips

  • Formulation: Sterile aqueous nasal spray containing 10 mg Semax.

  • Solubility: Fully soluble in sterile water and saline.

  • Storage: Refrigerated (2–8 °C); protect from light.

  • Stability: Stable for 12 months when refrigerated.

  • Handling: Shake gently before use; avoid freezing.

Important Note

For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.

Details

Formulation Type Pre-formulated nasal spray solution
Peptide Content 10 mg Semax per vial
Chemical Formula C37H51N9O10S
Molecular Mass ~869.9 Da
Appearance Clear, colorless aqueous solution
Intended Research Use Neuroprotection, ischemic injury, and cognitive function research
Storage Conditions Refrigerated (2–8 °C), protect from light
Handling Do not freeze; handle aseptically
Vial Size 10 mL

Research

Research Applications

Neuroprotection & Ischemic Injury

Semax has shown neuroprotective and anti-ischemic effects in preclinical and human models of stroke and hypoxia. It enhances neuronal survival and reduces oxidative stress through modulation of antioxidant enzymes and neurotrophic factors [Ashmarin 1998].

Cognitive Enhancement & Neuroplasticity

In studies on healthy volunteers and cognitive decline models, Semax increased BDNF and NGF expression, improving learning, memory, and attention. These findings suggest a role in synaptic plasticity and cortical adaptation [Inozemtseva 2008].

Stress & Inflammation Regulation

Semax modulates the hypothalamic–pituitary–adrenal (HPA) axis, reducing stress-induced behavioral and hormonal imbalances. It also lowers pro-inflammatory cytokine expression in brain tissue [Myasoedov 2009].

Neurodegenerative Disease Models

Semax has been investigated for potential in Alzheimer’s and Parkinson’s research due to its antioxidant, neurotrophic, and anti-apoptotic effects on dopaminergic and cholinergic neurons [Ashmarin 2005].

  • trigeminal pathways [Ashmarin 2005].

References

  1. Ashmarin IP, et al. (1998). Semax: Mechanisms of Action and Clinical Potential in Ischemic Brain Research. Neuroscience and Behavioral Physiology.
    https://link.springer.com/article/10.1007/BF02463168

  2. Inozemtseva LS, et al. (2008). Semax Regulates BDNF Expression in Rat Hippocampus Following Hypoxic Stress. Doklady Biological Sciences.
    https://pubmed.ncbi.nlm.nih.gov/18806861

  3. Myasoedov NF, et al. (2009). Peptide Neuroprotectors as Regulators of the Brain Stress System: Role of Semax. Biochemistry (Moscow).
    https://pubmed.ncbi.nlm.nih.gov/19548543

  4. Ashmarin IP, et al. (2005). Peptidergic Regulation of Brain Functions: Lessons from ACTH Analogues. Neuroscience and Behavioral Physiology.
    https://link.springer.com/article/10.1007/s11055-005-0078-3

Mechanism of Action

Mechanism of Action (How Semax Works)

  • Neurotrophin Upregulation: Increases BDNF, NGF, and TrkB receptor signaling for enhanced neuronal growth and repair [Inozemtseva 2008].

  • Antioxidant Defense: Boosts activity of SOD and catalase, reducing ROS accumulation [Ashmarin 1998].

  • Anti-Inflammatory Signaling: Decreases TNF-α and IL-6 while enhancing anti-inflammatory pathways [Myasoedov 2009].

  • Neurotransmitter Regulation: Modulates dopaminergic and serotonergic systems to stabilize mood and cognition [Ashmarin 2005].

  • CNS Delivery Pathway: Intranasal route allows efficient peptide transport to the brain via olfactory and trigeminal pathways [Ashmarin 2005].

References

  1. Ashmarin IP, et al. (1998). Semax: Mechanisms of Action and Clinical Potential in Ischemic Brain Research. Neuroscience and Behavioral Physiology.
    https://link.springer.com/article/10.1007/BF02463168

  2. Inozemtseva LS, et al. (2008). Semax Regulates BDNF Expression in Rat Hippocampus Following Hypoxic Stress. Doklady Biological Sciences.
    https://pubmed.ncbi.nlm.nih.gov/18806861

  3. Myasoedov NF, et al. (2009). Peptide Neuroprotectors as Regulators of the Brain Stress System: Role of Semax. Biochemistry (Moscow).
    https://pubmed.ncbi.nlm.nih.gov/19548543

  4. Ashmarin IP, et al. (2005). Peptidergic Regulation of Brain Functions: Lessons from ACTH Analogues. Neuroscience and Behavioral Physiology.
    https://link.springer.com/article/10.1007/s11055-005-0078-3

Certificate of Authenticity

No COA content added yet.

Related products