Description
NAD⁺ Spray (500mg)
Research-Grade Nicotinamide Adenine Dinucleotide Solution
Tagline: Cellular Energy & Neuroprotection Research
Product Description
Nicotinamide Adenine Dinucleotide (NAD⁺) is a vital coenzyme found in all living cells, serving as a key redox carrier in metabolic reactions. It plays a central role in mitochondrial function, DNA repair, oxidative stress response, and cellular longevity pathways.
The nasal spray formulation offers a unique delivery method for studying central nervous system (CNS) NAD⁺ modulation, bypassing hepatic metabolism and enabling research into neurodegeneration, cognitive function, and mitochondrial energetics.
For Laboratory and Scientific Research Use Only. Not for Human Consumption.
Why Researchers Choose NAD⁺ Nasal Spray
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Rapid CNS Research Delivery: Intranasal route allows direct NAD⁺ access to the brain through olfactory and trigeminal pathways.
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Cellular Energy Studies: Supports mitochondrial metabolism and ATP synthesis research.
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DNA Repair & Aging Research: Key cofactor in sirtuin and PARP-mediated genomic stability models.
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Neuroprotection & Oxidative Stress Studies: Investigated in models of ischemia, neurodegeneration, and inflammation.
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High Purity: Pharmaceutical-grade NAD⁺, ≥98% purity confirmed via HPLC.
Research Data & Handling Tips
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Formulation: Sterile aqueous nasal spray containing 500 mg NAD⁺.
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Solubility: Highly soluble in water and saline.
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Storage: Store refrigerated (2–8 °C), protect from light.
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Stability: Stable for up to 12 months refrigerated.
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Handling: Shake gently before use; avoid repeated freeze–thaw cycles.
Important Note
For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.
Research
Research Applications
Cellular Energy Metabolism
NAD⁺ functions as a key redox coenzyme in glycolysis, the TCA cycle, and oxidative phosphorylation, transferring electrons to produce ATP. Research shows that boosting NAD⁺ levels enhances mitochondrial function and bioenergetic efficiency in aging and metabolic disorder models [Yoshino 2018].
DNA Repair and Longevity Pathways
NAD⁺ is a required substrate for PARP and sirtuin enzymes, both crucial for DNA repair and genomic stability. Studies link NAD⁺ restoration to improved cellular stress responses and lifespan extension in mammalian models [Imai 2012].
Neuroprotection & Cognitive Function
Intranasal NAD⁺ administration has been investigated in models of stroke, neuroinflammation, and cognitive decline, demonstrating potential neuroprotective and anti-apoptotic effects via mitochondrial preservation [Liu 2017].
Oxidative Stress and Inflammation
By maintaining redox balance through NAD⁺/NADH cycling, supplementation reduces oxidative damage and inflammatory cytokine expression in cell culture and animal studies [Cantó 2015].
References
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Yoshino J, et al. (2018). NAD⁺ Intermediates: The Biology and Therapeutic Potential of NAD⁺ Metabolism. Cell Metabolism.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30404-0
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Imai S, Guarente L. (2012). NAD⁺ and Sirtuins in Aging and Disease. Trends in Cell Biology.
https://www.sciencedirect.com/science/article/pii/S0962892412001127
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Liu D, et al. (2017). Intranasal NAD⁺ administration exerts neuroprotective effects after ischemic stroke in mice. Frontiers in Neuroscience.
https://www.frontiersin.org/articles/10.3389/fnins.2017.00469/full
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Cantó C, Menzies KJ, Auwerx J. (2015). NAD⁺ Metabolism and the Control of Energy Homeostasis. Cell Metabolism.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00257-6
