N-Acetyl Semax - 10mg
N-Acetyl Semax - 10mg - Image 2

N-Acetyl Semax – 10mg

$45.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

N-Acetyl Semax (10 mg)

Research-Grade Modified ACTH-Derived Heptapeptide
Tagline: Neurotrophic & Cognitive Function Research

Product Description

N-Acetyl Semax is an acetylated analog of the ACTH(4-10) fragment, developed to improve stability, blood–brain barrier permeability, and resistance to enzymatic degradation compared with standard Semax. This modification enhances its potential in neuroprotection, nootropic function, and ischemic recovery research.

Researchers utilize N-Acetyl Semax to investigate its impact on BDNF and NGF regulation, synaptic plasticity, antioxidant defense, and neurotransmitter modulation. The acetyl group confers improved pharmacokinetic properties, extending peptide activity in in-vitro and in-vivo models.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose N-Acetyl Semax

  • Enhanced Stability: N-acetylation prolongs half-life and bioavailability.

  • Potent Neurotrophic Modulation: Upregulates BDNF and NGF signaling.

  • Cognitive & Learning Models: Improves attention, learning, and recall in behavioral studies.

  • Anti-Ischemic & Antioxidant Properties: Protects neural cells under oxidative stress.

  • High Purity: ≥ 98 % verified by HPLC and mass spectrometry.

Research Data & Handling Tips

  • Formulation: Lyophilized peptide powder for reconstitution.

  • Solubility: Soluble in sterile water or bacteriostatic water.

  • Storage: –20 °C (lyophilized); 2–8 °C after reconstitution.

  • Stability: 24 months (dry); use within 4-8 weeks once reconstituted.

  • Handling: Avoid repeated freeze–thaw cycles; protect from light.

Important Note

For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.

Details

Compound Name N-Acetyl Semax
Chemical Formula C39H57N9O10S
Molecular Mass ~ 887.0 Da
Sequence N-Ac-Met-Glu-His-Phe-Pro-Gly-Pro
Form Lyophilized peptide powder
Vial Size 10 mg
Solubility Water, saline, or PBS
Storage Conditions –20 °C (dry), 2–8 °C (after reconstitution)
Intended Research Use Neuroprotection, cognitive, and neuroplasticity studies

Research

Research Applications

Neuroprotection & Ischemic Injury

N-Acetyl Semax enhances neuronal survival under ischemic and oxidative stress conditions by regulating antioxidant enzymes (SOD, catalase) and promoting angiogenic and neurotrophic signaling [Ashmarin 1998].

Cognitive Enhancement & Learning

Behavioral and neurochemical studies show that Semax analogs improve learning, memory, and attention, likely through BDNF upregulation and synaptic plasticity enhancement [Inozemtseva 2008].

Neurotrophin Regulation (BDNF & NGF)

Acetylated Semax significantly increases BDNF mRNA in the hippocampus and prefrontal cortex, critical regions for learning and emotional regulation [Ashmarin 2005].

Stress Adaptation & Mood Stability

By modulating dopaminergic and serotonergic systems and reducing pro-inflammatory cytokines, N-Acetyl Semax contributes to enhanced stress resilience in laboratory stress models [Myasoedov 2009].

References

  1. Ashmarin IP, et al. (1998). Semax: Mechanisms of Action and Clinical Potential in Ischemic Brain Research. Neuroscience and Behavioral Physiology.
    https://link.springer.com/article/10.1007/BF02463168

  2. Inozemtseva LS, et al. (2008). Semax Regulates BDNF Expression in Rat Hippocampus Following Hypoxic Stress. Doklady Biological Sciences.
    https://pubmed.ncbi.nlm.nih.gov/18806861

  3. Ashmarin IP, et al. (2005). Peptidergic Regulation of Brain Functions: Lessons from ACTH Analogues. Neuroscience and Behavioral Physiology.
    https://link.springer.com/article/10.1007/s11055-005-0078-3

  4. Myasoedov NF, et al. (2009). Peptide Neuroprotectors as Regulators of the Brain Stress System: Role of Semax. Biochemistry (Moscow).
    https://pubmed.ncbi.nlm.nih.gov/19548543

Mechanism of Action

Mechanism of Action (How N-Acetyl Semax Works)

  • Neurotrophin Activation: Upregulates BDNF and NGF pathways supporting neuronal growth and plasticity [Inozemtseva 2008].

  • Antioxidant Defense: Enhances SOD and catalase activity, protecting against ROS-induced damage [Ashmarin 1998].

  • Neurotransmitter Regulation: Balances dopamine and serotonin levels in limbic and cortical regions [Ashmarin 2005].

  • Anti-Inflammatory Response: Reduces TNF-α and IL-6 while increasing IL-10 expression [Myasoedov 2009].

  • Improved CNS Stability: N-acetyl modification resists enzymatic degradation and increases peptide half-life for extended research applications.

References

  1. Ashmarin IP, et al. (1998). Semax: Mechanisms of Action and Clinical Potential in Ischemic Brain Research. Neuroscience and Behavioral Physiology.
    https://link.springer.com/article/10.1007/BF02463168

  2. Inozemtseva LS, et al. (2008). Semax Regulates BDNF Expression in Rat Hippocampus Following Hypoxic Stress. Doklady Biological Sciences.
    https://pubmed.ncbi.nlm.nih.gov/18806861

  3. Ashmarin IP, et al. (2005). Peptidergic Regulation of Brain Functions: Lessons from ACTH Analogues. Neuroscience and Behavioral Physiology.
    https://link.springer.com/article/10.1007/s11055-005-0078-3

  4. Myasoedov NF, et al. (2009). Peptide Neuroprotectors as Regulators of the Brain Stress System: Role of Semax. Biochemistry (Moscow).
    https://pubmed.ncbi.nlm.nih.gov/19548543

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