Melanotan II Spray 10MG

Melanotan II Spray 10MG

$39.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

Our Spray Kits Come unassembled. They include
– Melanotan II 10mg Vial
– 3ML Luer Lock Syringe
– Spray Bottle
– 10ML Bacteriostatic Water

Only 9 left in stock

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Description

Melanotan II Spray (10mg)

Research-Grade Melanocortin Analogue
Tagline: Photoprotection & Neuromodulation Research

Product Description

Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of α-MSH (alpha-melanocyte-stimulating hormone), developed for research on the melanocortin receptor system. It is primarily used in preclinical models to study melanogenesis, sexual behavior modulation, energy homeostasis, and neuroendocrine signaling.

The nasal spray formulation enables researchers to evaluate central nervous system delivery via the olfactory route, providing an alternative to injectable administration for studying neuropeptide transport and systemic activity.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose Melanotan II Nasal Spray

  • Melanocortin Receptor Model: Targets MC1R and MC4R receptors for photoprotection and sexual behavior studies.

  • Intranasal Delivery: Enables direct access to CNS pathways through nasal mucosa absorption.

  • Photobiology Research: Supports investigation into pigmentation and UV-protective mechanisms.

  • Energy & Appetite Regulation: Used to explore metabolic and hypothalamic signaling pathways.

  • High Purity: ≥98% purity confirmed via HPLC and mass spectrometry testing.

Research Data & Handling Tips

  • Formulation: Pre-formulated 10 mg peptide in isotonic nasal spray solution.

  • Solubility: Water, saline, or PBS.

  • Storage: Store refrigerated (2–8 °C), protect from light.

  • Stability: Stable for 12 months refrigerated; avoid repeated temperature fluctuations.

  • Handling: Shake gently before each use; do not freeze.

Important Note

For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.

Details

Formulation Type Pre-formulated nasal spray solution
Peptide Content 10 mg Melanotan II per vial
Chemical Formula C50H69N15O9
Molecular Mass ~1024.18 Da
Appearance Clear, colorless aqueous solution
Intended Research Use Photoprotection, melanogenesis, neuroendocrine, and metabolic studies
Storage Conditions Refrigerated (2–8 °C), protect from light
Handling Do not freeze; handle aseptically
Vial Size 10 mL

Research

Research Applications

Melanogenesis & Photoprotection

Melanotan II acts as a potent agonist at the MC1R receptor, increasing eumelanin production in melanocytes and reducing UV-induced DNA damage. Studies show it enhances tanning responses and photoprotective effects in skin models [Eves 2000].

Neuroendocrine and Sexual Function Research

MT-II activates MC3R and MC4R receptors in the hypothalamus, influencing sexual arousal and energy regulation. Preclinical work has linked these pathways to central melanocortin signaling mechanisms [Wessells 2000].

Appetite and Energy Homeostasis

The melanocortin system is a central regulator of feeding behavior and energy expenditure. MT-II administration in animal models has shown appetite suppression and metabolic modulation through MC4R activity [Cone 2005].

Neurological and Behavioral Models

Research suggests MT-II may modulate stress response, reward behavior, and inflammatory signaling through CNS melanocortin circuits [Catania 2000].

References

  1. Eves PC, et al. (2000). Melanocortin-induced melanogenesis and photoprotection. Pigment Cell Res.
    https://pubmed.ncbi.nlm.nih.gov/11041202/

  2. Wessells H, et al. (2000). Melanocortin receptor agonists and sexual function: Mechanistic insights. J Urol.
    https://pubmed.ncbi.nlm.nih.gov/11025701/

  3. Cone RD. (2005). Anatomy and regulation of the central melanocortin system. Nat Neurosci.
    https://www.nature.com/articles/nn1455

  4. Catania A, et al. (2000). The melanocortin system in inflammation and immunity. Peptides.
    https://pubmed.ncbi.nlm.nih.gov/10876055/

Mechanism of Action

Mechanism of Action (How Melanotan II Works)

  • MC1R Activation: Stimulates melanocytes to increase melanin synthesis for pigmentation and photoprotection [Eves 2000].

  • MC3R/MC4R Agonism: Engages hypothalamic pathways regulating appetite, metabolism, and sexual behavior [Cone 2005].

  • Central Nervous System Delivery: Nasal absorption may facilitate peptide access to CNS tissues for neurobehavioral studies [Wessells 2000].

  • Anti-Inflammatory Effects: Melanocortin receptor activation reduces cytokine expression and modulates immune signaling [Catania 2000].

  • Energy Balance Regulation: Enhances leptin-melanocortin pathway activity, contributing to thermogenesis and weight regulation [Cone 2005].

References

  1. Eves PC, et al. (2000). Melanocortin-induced melanogenesis and photoprotection. Pigment Cell Res.
    https://pubmed.ncbi.nlm.nih.gov/11041202/

  2. Wessells H, et al. (2000). Melanocortin receptor agonists and sexual function: Mechanistic insights. J Urol.
    https://pubmed.ncbi.nlm.nih.gov/11025701/

  3. Cone RD. (2005). Anatomy and regulation of the central melanocortin system. Nat Neurosci.
    https://www.nature.com/articles/nn1455

  4. Catania A, et al. (2000). The melanocortin system in inflammation and immunity. Peptides.
    https://pubmed.ncbi.nlm.nih.gov/10876055/

 

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