Kisspeptin - 10mg
Kisspeptin - 10mg - Image 2

Kisspeptin – 10mg

$59.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

Kisspeptin (Metastin)

Research-Grade Neuropeptide
Tagline: Reproductive Axis & GnRH Research

Product Description

Kisspeptin (also known as Metastin or KISS1-derived peptide) is a neuropeptide encoded by the KISS1 gene, and is the endogenous ligand for the GPR54 (KISS1R) receptor. It plays a crucial role in puberty onset, hypothalamic-pituitary-gonadal (HPG) axis regulation, and reproductive function.

Researchers use Kisspeptin in preclinical and clinical models to study GnRH secretion, LH/FSH release, fertility regulation, and neuroendocrine control of reproduction. It is also studied for its role in cancer metastasis suppression and energy homeostasis.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose Kisspeptin

  • Key Regulator of Reproduction: Direct stimulator of GnRH neurons and pituitary gonadotropin release.

  • Puberty Research Applications: Studied for its role in initiating reproductive maturity.

  • Cancer Metastasis Studies: Inhibits tumor metastasis in several experimental models.

  • Energy Balance & Neuroendocrine Links: Explored in research on leptin and nutritional regulation of fertility.

  • Batch Verified: High-purity peptide (≥98%) for reproducible results.

Research Data & Handling Tips

  • Reconstitution: Reconstitute with sterile water or PBS; swirl gently to dissolve.

  • Solubility: Water-soluble; prepare fresh aliquots and freeze for long-term use.

  • Storage: Store lyophilized peptide at -20 °C. After reconstitution, aliquot and store at -80 °C.

  • Stability: Stable for up to 24 months (lyophilized). Use within 4–8 weeks once reconstituted.

Important Note

For laboratory and scientific research only. Not for human consumption, veterinary use, or diagnostic purposes.

Details

<table style=”width:100%; border-collapse: collapse;”> <tr> <td><strong>Chemical Formula</strong></td> <td>C₆₅H₈₁N₁₇O₁₉</td> </tr> <tr> <td><strong>Molecular Mass</strong></td> <td>~1302.4 Da (Kisspeptin-10 fragment)</td> </tr> <tr> <td><strong>CAS Number</strong></td> <td>286708-19-8 (Kisspeptin-10)</td> </tr> <tr> <td><strong>Vial Size</strong></td> <td>1 mg, 5 mg, 10 mg</td> </tr> <tr> <td><strong>Form</strong></td> <td>Lyophilized peptide powder</td> </tr> <tr> <td><strong>Solubility</strong></td> <td>Water, PBS, cell culture media</td> </tr> <tr> <td><strong>Shelf Life</strong></td> <td>24 months (lyophilized)</td> </tr> <tr> <td><strong>Handling</strong></td> <td>Protect from light and moisture; avoid repeated freeze-thaw cycles</td> </tr> <tr> <td><strong>Intended Use</strong></td> <td>For preclinical and in vitro research only</td> </tr> <tr> <td><strong>Storage</strong></td> <td>-20 °C (dry powder), -80 °C (after reconstitution)</td> </tr> </table>

Research

Research Applications

GnRH & Gonadotropin Release Studies

Kisspeptin potently stimulates GnRH release from hypothalamic neurons, resulting in LH and FSH secretion from the anterior pituitary [1].

Puberty Onset & Fertility Models

Knockout studies show kisspeptin signaling is essential for normal puberty and reproductive function [2].

Cancer Research

Kisspeptin was initially identified as a metastasis suppressor, making it relevant in oncology research [3].

Metabolic-Endocrine Link

Investigated as a mediator of leptin’s effects on fertility, linking energy status to reproductive capacity [4].

References

  1. Seminara SB et al. (2003). The GPR54 Gene as a Regulator of Puberty. NEJM.
    https://www.nejm.org/doi/pdf/10.1056/NEJMoa035322

  2. d’Anglemont de Tassigny X et al. (2007). Role of Kisspeptin Signaling in Puberty Onset. Endocrinology.
    https://journals.physiology.org/doi/pdf/10.1152/physiol.00009.2010

  3. Lee JH et al. (1996). KISS1 as a Metastasis Suppressor Gene. Nature.
    https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/88.23.1731

  4. Castellano JM et al. (2009). Kisspeptin as a Mediator of Metabolic Control of Fertility. Endocr Rev.
    https://www.sciencedirect.com/science/article/pii/S0196978108002659

Mechanism of Action

Mechanism of Action (How Kisspeptin Works)

  • GPR54 (KISS1R) Activation: Kisspeptin binds to its receptor on GnRH neurons, triggering GnRH release [Seminara 2003].

  • GnRH Cascade Initiation: Activates the hypothalamic-pituitary-gonadal axis, leading to LH/FSH release and downstream sex steroid production [d’Anglemont de Tassigny 2007].

  • Puberty Trigger: Essential for the timing of puberty and reproductive maturation [Seminara 2003].

  • Metastasis Suppression: Inhibits tumor metastasis via modulation of cell adhesion and migration genes [Lee 1996].

  • Metabolic Integration: Communicates nutritional status to reproductive centers, coordinating fertility with energy availability [Castellano 2009].

References

  1. Seminara SB et al. (2003). The GPR54 Gene as a Regulator of Puberty. NEJM.
    https://www.nejm.org/doi/pdf/10.1056/NEJMoa035322

  2. d’Anglemont de Tassigny X et al. (2007). Role of Kisspeptin Signaling in Puberty Onset. Endocrinology.
    https://journals.physiology.org/doi/pdf/10.1152/physiol.00009.2010

  3. Lee JH et al. (1996). KISS1 as a Metastasis Suppressor Gene. Nature.
    https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/88.23.1731

  4. Castellano JM et al. (2009). Kisspeptin as a Mediator of Metabolic Control of Fertility. Endocr Rev.
    https://www.sciencedirect.com/science/article/pii/S0196978108002659

Certificate of Authenticity

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