Description
IGF-1 LR3 (1 mg)
Research-Grade Long R3 Insulin-Like Growth Factor-1
Tagline: Cell Growth & Regeneration Research
Product Description
IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor-1) is a synthetic, recombinant analog of human IGF-1 engineered for enhanced stability and bioactivity. The substitution of arginine for glutamic acid at position 3 and an extended 13-amino-acid N-terminal sequence prevent binding to IGF-binding proteins, significantly increasing its biological half-life.
Researchers use IGF-1 LR3 in cellular growth, muscle regeneration, metabolic, and neuroprotective studies, where it mimics the anabolic actions of insulin-like growth factor-1 while offering longer receptor interaction time and increased potency.
For Laboratory and Scientific Research Use Only. Not for Human Consumption.
Why Researchers Choose IGF-1 LR3
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Extended Half-Life: Modified structure prevents binding to IGFBPs, extending activity duration.
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Cellular Growth & Regeneration: Stimulates myoblast proliferation, differentiation, and repair.
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Insulin-Mimetic & Metabolic Effects: Activates PI3K/Akt pathway for nutrient uptake and cell survival.
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Neuroprotective Research Applications: Studied in models of neurodegeneration and ischemia.
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High Purity: ≥98% verified via HPLC and mass spectrometry.
Research Data & Handling Tips
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Formulation: Lyophilized peptide powder for reconstitution.
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Solubility: Soluble in sterile water, acetic acid, or buffer.
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Storage: Store lyophilized powder at –20 °C; refrigerate reconstituted solution (2–8 °C).
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Stability: 24 months (lyophilized); use within 2 weeks of reconstitution.
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Handling: Avoid repeated freeze–thaw cycles; protect from light.
Important Note
For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.
Research
Research Applications
Muscle Growth & Repair
IGF-1 LR3 stimulates myoblast proliferation and differentiation, enhancing muscle regeneration and recovery in cellular and animal models. It promotes muscle hypertrophy by activating PI3K/Akt/mTOR signaling, a key regulator of protein synthesis [Adams 2000].
Neuroprotection & CNS Regeneration
Studies show IGF-1 and its analogs reduce neuronal apoptosis and enhance survival in ischemic and neurodegenerative models through activation of Akt and ERK pathways, improving cognitive recovery and neuroplasticity [Fernandez 2007].
Cellular Metabolism & Insulin Signaling
IGF-1 LR3 mimics insulin activity by increasing glucose uptake and glycogen synthesis via activation of the IGF-1R–IRS–Akt cascade. It is used to explore metabolic regulation, glucose transport, and mitochondrial biogenesis [Clemmons 2009].
Tissue Regeneration & Wound Healing
In vitro and in vivo data demonstrate IGF-1 enhances fibroblast migration, collagen production, and angiogenesis, supporting wound closure and vascularization research [Liu 2010].
References
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Adams GR, et al. (2000). Role of IGF-1 in skeletal muscle hypertrophy and repair. Am J Physiol Endocrinol Metab.
https://journals.physiology.org/doi/full/10.1152/ajpendo.2000.279.6.E1179
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Fernandez AM, Torres-Aleman I. (2007). The many faces of insulin-like peptides: neurotrophic and metabolic functions. Trends Endocrinol Metab.
https://www.sciencedirect.com/science/article/pii/S1043276007000983
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Clemmons DR. (2009). Role of IGF-1 in glucose and lipid metabolism. Endocr Rev.
https://academic.oup.com/edrv/article/30/1/90/2355180
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Liu JP, et al. (2010). IGF-1 signaling in wound healing and tissue regeneration. Growth Horm IGF Res.
https://www.sciencedirect.com/science/article/pii/S1096637410000241
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Humbel RE. (1990). Insulin-like growth factors I and II. Eur J Biochem.
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1432-1033.1990.tb15648.x
