HMG - 75IU
HMG - 75IU - Image 2

HMG – 75IU

$49.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

HMG (Human Menopausal Gonadotropin)

Research-Grade Gonadotropin Preparation
Tagline: FSH & LH Research for Reproductive Studies

Product Description

HMG (Human Menopausal Gonadotropin) is a purified preparation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) obtained from the urine of postmenopausal women. It is widely used in research to study ovarian follicle development, spermatogenesis, steroidogenesis, and reproductive endocrinology.

Researchers utilize HMG in in vitro and animal models to investigate pituitary-gonadal signaling, gonadotropin responsiveness, and assisted reproduction protocols. Its combined LH/FSH activity makes it a versatile research tool for both male and female reproductive studies.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose HMG

  • Dual Gonadotropin Activity: Contains both LH and FSH for comprehensive reproductive axis stimulation.

  • Well-Characterized Source: Purified from human biological material under GMP conditions.

  • Reproductive Research Tool: Ideal for follicular stimulation and spermatogenesis studies.

  • Validated Activity: Bioassayed for potency and standardized to USP units.

  • Batch Verified: Tested for sterility, pyrogenicity, and hormone activity before release.

Research Data & Handling Tips

  • Reconstitution: Reconstitute with sterile water or bacteriostatic water; mix gently until dissolved.

  • Solubility: Fully soluble in water and physiological buffers.

  • Storage: Store lyophilized powder at 2–8 °C. After reconstitution, refrigerate and use promptly.

  • Stability: Stable for 24 months (lyophilized); use within 4–8 weeks after reconstitution.

Important Note

For laboratory and scientific research only. Not for human consumption, clinical use, or diagnostic purposes.

Details

Composition Highly purified human FSH and LH
FSH:LH Ratio Approx. 1:1 (75 IU FSH / 75 IU LH per vial)
CAS Number 9002-68-0 (FSH), 9002-67-9 (LH)
Vial Size 75 IU / 150 IU per vial (custom sizes available)
Form Lyophilized protein preparation
Solubility Water, PBS, cell culture media
Shelf Life 24 months (unopened, refrigerated)
Handling Use aseptic technique; avoid vigorous shaking
Intended Use For preclinical, in vitro, and animal model research
Storage 2–8 °C (lyophilized), do not freeze solution

Research

Research Applications

Folliculogenesis & Ovarian Function

HMG stimulates ovarian follicles in animal models, making it a key tool for research on follicular maturation and ovulation induction [1].

Spermatogenesis Studies

Used to induce spermatogenesis in hypogonadal male models by stimulating Sertoli and Leydig cell function [2].

Steroidogenesis & Endocrine Pathways

Activates LH/FSH receptors, promoting estradiol, progesterone, and testosterone production for endocrine research [3].

Assisted Reproduction Protocol Research

In reproductive science, HMG is used to develop protocols for controlled ovarian hyperstimulation and superovulation [4].

References

  1. Filicori M et al. (2005). Mechanisms of Follicular Recruitment with Human Menopausal Gonadotropins. Fertil Steril.
    https://link.springer.com/chapter/10.1007/978-1-4684-4712-5_7

  2. Schaison G et al. (1993). HMG and Spermatogenesis Induction in Hypogonadotropic Hypogonadism. JCEM.
    https://academic.oup.com/jcem/article-abstract/77/6/1545/2650302

  3. Themmen AP et al. (2000). FSH and LH Receptor Signaling Pathways. Endocr Rev.
    https://academic.oup.com/edrv/article/21/5/551/2424075

  4. Shoham Z (1994). Controlled Ovarian Hyperstimulation Using HMG Preparations. Fertil Steril.
    https://www.fertstert.org/article/S0015-0282%2802%2903157-6/fulltext

Mechanism of Action

Mechanism of Action (How HMG Works)

  • FSH Receptor Activation: Stimulates granulosa cells in the ovary to promote follicle growth and estradiol production [Themmen 2000].

  • LH Receptor Activation: Stimulates theca and Leydig cells, increasing androgen and testosterone production [Schaison 1993].

  • HPG Axis Modeling: Mimics pituitary gonadotropin signaling, allowing study of reproductive feedback loops [Filicori 2005].

  • Dual Hormone Synergy: Combined FSH and LH activity enables complete gonadal stimulation in research models [Shoham 1994].

  • Steroidogenic Enzyme Upregulation: Increases aromatase and 17β-HSD activity for steroidogenesis research [Themmen 2000].

References

  1. Filicori M et al. (2005). Mechanisms of Follicular Recruitment with Human Menopausal Gonadotropins. Fertil Steril.
    https://link.springer.com/chapter/10.1007/978-1-4684-4712-5_7

  2. Schaison G et al. (1993). HMG and Spermatogenesis Induction in Hypogonadotropic Hypogonadism. JCEM.
    https://academic.oup.com/jcem/article-abstract/77/6/1545/2650302

  3. Themmen AP et al. (2000). FSH and LH Receptor Signaling Pathways. Endocr Rev.
    https://academic.oup.com/edrv/article/21/5/551/2424075

  4. Shoham Z (1994). Controlled Ovarian Hyperstimulation Using HMG Preparations. Fertil Steril.
    https://www.fertstert.org/article/S0015-0282%2802%2903157-6/fulltext

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