GHRP-2 - 5mg
GHRP-2 - 5mg - Image 2

GHRP-2 – 5mg

$19.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

GHRP-2 (Growth Hormone Releasing Peptide-2)

Research-Grade Hexapeptide
Tagline: GH Secretion & Metabolic Research

Product Description

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide and ghrelin receptor (GHS-R1a) agonist that potently stimulates growth hormone (GH) release from the anterior pituitary.

Researchers use GHRP-2 in preclinical and in vitro studies to investigate GH axis physiology, IGF-1 production, metabolism, and hypothalamic regulation of appetite and energy balance.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose GHRP-2

  • Potent GH Secretagogue: Stronger GH-releasing activity compared to GHRP-6.

  • Ghrelin Mimetic: Activates GHS-R1a, allowing study of hunger and metabolic signaling.

  • Synergistic Effects: Studied in combination with GHRH analogues like CJC-1295 to amplify GH pulses.

  • Endocrine Research Tool: Ideal for modeling GH/IGF-1 axis function.

  • Batch Verified: ≥98% purity, HPLC and MS confirmed.

Research Data & Handling Tips

  • Reconstitution: Reconstitute lyophilized peptide with bacteriostatic water; swirl gently until dissolved.

  • Solubility: Fully soluble in water or PBS.

  • Storage: Store lyophilized peptide at -20 °C. After reconstitution, aliquot and store at -80 °C.

  • Stability: Stable for 24 months (lyophilized); use within 4–8 weeks once reconstituted.

Important Note

For laboratory and scientific research only. Not for human consumption, veterinary use, or diagnostic purposes.

Details

Chemical Formula C₄₅H₅₅N₉O₆
Molecular Mass 817.0 Da
CAS Number 158861-67-7
Vial Size 5 mg, 10 mg
Form Lyophilized peptide powder
Solubility Water, PBS, sterile buffer
Shelf Life 24 months (lyophilized)
Handling Protect from light; avoid repeated freeze-thaw cycles
Intended Use For preclinical and in vitro research only
Storage -20 °C (dry powder), -80 °C (after reconstitution)

Research

Research Applications

Growth Hormone Axis Studies

GHRP-2 potently stimulates GH release independent of GHRH, making it valuable for pituitary responsiveness research [1].

IGF-1 Production & Protein Synthesis

Used to investigate hepatic IGF-1 production and its role in muscle protein metabolism [2].

Appetite & Energy Regulation

Activates hypothalamic ghrelin receptors, increasing food intake in animal models [3].

Combination Studies

Synergizes with GHRH analogues for enhanced pulsatile GH secretion, useful in endocrinology models [4].

References

  1. Bowers CY et al. (1990). GH-Releasing Peptide-2: A New Hypothalamic Secretagogue. Endocrinology.
    https://www.sciencedirect.com/science/article/pii/0026049595900160

  2. Svensson J et al. (1998). Effects of GHRP-2 on IGF-1 Production and Protein Metabolism. J Clin Endocrinol Metab.
    https://www.sciencedirect.com/science/article/pii/S0091302297901588

  3. Kojima M et al. (1999). Discovery of Ghrelin and Its Receptor. Nature.
    https://reference.medscape.com/medline/abstract/10604470

  4. Bowers CY et al. (1992). Synergistic Effects of GHRP-2 and GHRH. JCEM.
    https://link.springer.com/chapter/10.1007/978-1-59259-015-5_2

Mechanism of Action

Mechanism of Action (How GHRP-2 Works)

  • Ghrelin Receptor Agonism: Binds to GHS-R1a on pituitary somatotrophs and hypothalamic neurons, stimulating GH release [Bowers 1990].

  • Somatostatin Suppression: Reduces hypothalamic somatostatin output, allowing greater GH pulse amplitude [Bowers 1992].

  • Hunger Stimulation: Activates NPY/AgRP neurons in the arcuate nucleus, increasing appetite [Kojima 1999].

  • IGF-1 Pathway Activation: Increases circulating IGF-1, supporting anabolic signaling and tissue repair [Svensson 1998].

  • Synergistic with GHRH: Amplifies GH secretion when combined with GHRH analogues [Bowers 1992].

References

  1. Bowers CY et al. (1990). GH-Releasing Peptide-2: A New Hypothalamic Secretagogue. Endocrinology.
    https://www.sciencedirect.com/science/article/pii/0026049595900160

  2. Svensson J et al. (1998). Effects of GHRP-2 on IGF-1 Production and Protein Metabolism. J Clin Endocrinol Metab.
    https://www.sciencedirect.com/science/article/pii/S0091302297901588

  3. Kojima M et al. (1999). Discovery of Ghrelin and Its Receptor. Nature.
    https://reference.medscape.com/medline/abstract/10604470

  4. Bowers CY et al. (1992). Synergistic Effects of GHRP-2 and GHRH. JCEM.
    https://link.springer.com/chapter/10.1007/978-1-59259-015-5_2

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