B12 (Methylated) - 10mg
B12 (Methylated) - 10mg - Image 2

B12 (Methylated) – 10mg

$35.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

B12 (Cobalamin)

Research-Grade Water-Soluble Vitamin
Tagline: Methylation & Energy Metabolism Research

Product Description

Vitamin B12 (Cobalamin) is an essential, water-soluble vitamin that serves as a cofactor in several critical enzymatic reactions, including DNA synthesis, methylation cycles, and energy metabolism. In research, B12 is commonly studied to understand its roles in neurological function, red blood cell production, and homocysteine metabolism.

Researchers use Vitamin B12 in preclinical models to explore methylation status, one-carbon metabolism, nervous system development, and anemia mechanisms. Different forms (methylcobalamin, cyanocobalamin, hydroxocobalamin, adenosylcobalamin) are used to study specific biochemical pathways.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose Vitamin B12

  • Multiple Biologically Active Forms: Allows pathway-specific studies (methylation vs mitochondrial metabolism).

  • Key Coenzyme Role: Cofactor for methionine synthase and methylmalonyl-CoA mutase.

  • Methylation Research: Critical for one-carbon metabolism and SAM cycle studies.

  • Neurobiology Relevance: Studied for its role in myelin synthesis and cognitive health.

  • Batch Verified: High-purity (≥98%) and identity confirmed for reproducibility.

Research Data & Handling Tips

  • Reconstitution: Dissolve powder in water or suitable buffer for in vitro use.

  • Solubility: Water-soluble; light-sensitive (protect from direct light).

  • Storage: Store at 2–8 °C (protected from light and air).

  • Stability: Stable for up to 24 months (lyophilized). Use within 4–8 weeks after reconstitution.

Important Note

For laboratory and scientific research only. Not for human consumption, veterinary use, or diagnostic purposes.

Additional information

Size

10mg I 20mg

Details

Chemical Formula C₆₃H₈₈CoN₁₄O₁₄P
Molecular Mass ~1355.4 g/mol
CAS Number 68-19-9 (Cyanocobalamin)
Vial Size 100 mg, 500 mg, 1 g
Form Crystalline powder (Cyanocobalamin or Methylcobalamin available)
Solubility Water, slightly soluble in alcohol
Shelf Life 24 months (protected from light)
Handling Use aseptic technique; store in airtight container away from light
Intended Use For preclinical and in vitro research only
Storage 2–8 °C (refrigerated), desiccated and light-protected

Research

Research Applications

Methylation & Epigenetic Studies

B12 serves as a cofactor for methionine synthase, converting homocysteine to methionine and supporting DNA methylation [1].

Hematology & Anemia Models

Deficiency studies are used to model megaloblastic anemia and understand red blood cell maturation [2].

Neurological & Cognitive Research

Supports myelin formation and neurotransmitter synthesis; deficiency linked to neurodegeneration [3].

Mitochondrial & Energy Metabolism

Adenosylcobalamin form is a cofactor for methylmalonyl-CoA mutase, involved in odd-chain fatty acid metabolism [4].

References

  1. Green R et al. (2017). Vitamin B12 Deficiency and One-Carbon Metabolism. NEJM.
    https://pure.au.dk/portal/en/publications/vitamin-b12-deficiency

  2. O’Leary F et al. (2010). Hematologic Manifestations of B12 Deficiency. Blood Rev.
    https://www.mdpi.com/2072-6643/2/3/299

  3. Moore E et al. (2012). Cobalamin and Neurodegeneration: Clinical and Preclinical Evidence. Nutrients.
    https://europepmc.org/abstract/MED/22221769

  4. Hannibal L et al. (2016). Mitochondrial Function and Cobalamin-Dependent Enzymes. Mol Genet Metab.
    https://www.degruyterbrill.com/document/doi/10.1515/cclm-2012-0568/pdf

Mechanism of Action

Mechanism of Action (How Vitamin B12 Works)

  • Cofactor for Methionine Synthase: Catalyzes conversion of homocysteine to methionine, maintaining methylation capacity [Green 2017].

  • Cofactor for Methylmalonyl-CoA Mutase: Facilitates conversion of methylmalonyl-CoA to succinyl-CoA, critical for energy metabolism [Hannibal 2016].

  • Supports DNA Synthesis: Required for purine and thymidylate synthesis during cell division [O’Leary 2010].

  • Maintains Myelin Integrity: Essential for myelin sheath formation and nervous system function [Moore 2012].

  • Regulates Homocysteine Levels: Helps prevent hyperhomocysteinemia, which is linked to cardiovascular risk [Green 2017].

References

  1. Green R et al. (2017). Vitamin B12 Deficiency and One-Carbon Metabolism. NEJM.
    https://pure.au.dk/portal/en/publications/vitamin-b12-deficiency

  2. O’Leary F et al. (2010). Hematologic Manifestations of B12 Deficiency. Blood Rev.
    https://www.mdpi.com/2072-6643/2/3/299

  3. Moore E et al. (2012). Cobalamin and Neurodegeneration: Clinical and Preclinical Evidence. Nutrients.
    https://europepmc.org/abstract/MED/22221769

  4. Hannibal L et al. (2016). Mitochondrial Function and Cobalamin-Dependent Enzymes. Mol Genet Metab.
    https://www.degruyterbrill.com/document/doi/10.1515/cclm-2012-0568/pdf

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