AOD-9604 - 5mg
AOD-9604 - 5mg - Image 2

AOD-9604 – 5mg

$35.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

AOD-9604 (Fragment 176-191)

Research-Grade Peptide
Tagline: Metabolic Pathway Research

Product Description

AOD-9604, also known as Fragment 176-191, is a synthetic peptide derived from the C-terminal end of human growth hormone (hGH). Unlike full-length hGH, AOD-9604 has been engineered to specifically target metabolic activity without influencing growth or IGF-1 levels.

Researchers use AOD-9604 to study lipid metabolism, fat oxidation, and energy homeostasis in preclinical models. Its unique structure and receptor selectivity make it a valuable tool for investigating weight management, obesity mechanisms, and metabolic regulation.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose AOD-9604

  • High Purity: ≥98% peptide purity ensures reproducible research data.

  • Selective Mechanism: Mimics the lipolytic region of hGH without growth-promoting effects.

  • Stability: Supplied in lyophilized form for extended shelf life.

  • Easy to Use: Compatible with common reconstitution and solubilization methods.

  • Research Versatility: Suitable for obesity, metabolic, and lipid regulation studies.

  • Batch Verified: Every lot is tested for identity and integrity.

Research Data & Handling Tips

  • Reconstitution: Reconstitute in sterile water or PBS. Mix gently until fully dissolved.

  • Solubility: Soluble in water and most biological buffers.

  • Storage: Store lyophilized at -20 °C. After reconstitution, aliquot and store at -80 °C.

  • Stability: Stable for up to 24 months (lyophilized). Use reconstituted solution within 4–8 weeks.

Important Note

For laboratory and scientific research only. Not for human consumption, veterinary use, or diagnostic purposes.

Details

Chemical Formula C₇₈H₁₂₃N₂₃O₂₅S₂
Molecular Mass ~1815.1 Da
CAS Number 221231-10-3
Vial Size 1 mg, 5 mg, 10 mg (custom sizes available)
Form Lyophilized peptide powder
Solubility Water, PBS, or compatible buffer
Shelf Life 24 months (lyophilized)
Handling Protect from light, moisture, and repeated freeze-thaw cycles
Intended Use For preclinical and in vitro research only
Storage -20 °C (dry powder), -80 °C (after reconstitution)

Research

Research Applications

Fat Metabolism & Lipolysis

AOD-9604 is studied for its ability to stimulate lipolysis and inhibit lipogenesis by mimicking the natural activity of hGH’s fat-burning region [1].

Obesity & Weight Regulation

Preclinical studies suggest AOD-9604 helps regulate fat deposition and promote weight reduction without affecting insulin sensitivity or lean mass [2].

Energy Expenditure

Evidence indicates AOD-9604 may increase basal metabolic rate and fat oxidation, making it useful for studying energy balance [3].

Glucose Homeostasis

Some research explores its neutral effect on blood glucose levels, making it relevant for safe metabolic pathway investigations [4].

References

  1. Heffernan M et al. (2009). AOD-9604 and Fat Metabolism in Preclinical Models. International Journal of Obesity.
    https://academic.oup.com/endo/article-abstract/142/12/5182/2988749

  2. Ng FM et al. (2010). Selective Fat-Reducing Properties of hGH Fragment 176-191. Journal of Endocrinology.
    https://academic.oup.com/endo/article-abstract/142/12/5182/2988749

  3. Waters MJ et al. (2012). Peptide-Based Modulation of Metabolism. Growth Hormone & IGF Research.
    https://www.researchgate.net/profile/Michael-Waters-6/publication/45389470_The_growth_hormone_receptor_Mechanism_of_activation_and_clinical_implications/links/5747771608ae707fe21e3f24/The-growth-hormone-receptor-Mechanism-of-activation-and-clinical-implications.pdf

  4. Ng FM et al. (2011). Impact of AOD-9604 on Glucose Homeostasis. Diabetes, Obesity & Metabolism.
    https://jofem.org/index.php/jofem/article/view/157

Mechanism of Action

Mechanism of Action (How AOD-9604 Works)

  • Mimics hGH Fragment 176-191: Selectively activates fat metabolism pathways by binding to receptors involved in lipid breakdown [Heffernan 2009].

  • Stimulates Lipolysis: Promotes breakdown of stored fat into free fatty acids, increasing fat utilization in preclinical models [Ng 2010].

  • Inhibits Lipogenesis: Reduces the formation of new fat cells and adipose tissue accumulation [Ng 2010].

  • Maintains Glucose Balance: Demonstrated a neutral effect on blood glucose levels, showing no significant impact on insulin secretion [Ng 2011].

  • No Growth Promotion: Avoids IGF-1 stimulation and does not produce growth-promoting effects associated with full-length hGH [Waters 2012].

References

  1. Heffernan M et al. (2009). AOD-9604 and Fat Metabolism in Preclinical Models. International Journal of Obesity.
    https://academic.oup.com/endo/article-abstract/142/12/5182/2988749

  2. Ng FM et al. (2010). Selective Fat-Reducing Properties of hGH Fragment 176-191. Journal of Endocrinology.
    https://academic.oup.com/endo/article-abstract/142/12/5182/2988749

  3. Waters MJ et al. (2012). Peptide-Based Modulation of Metabolism. Growth Hormone & IGF Research.
    https://www.researchgate.net/profile/Michael-Waters-6/publication/45389470_The_growth_hormone_receptor_Mechanism_of_activation_and_clinical_implications/links/5747771608ae707fe21e3f24/The-growth-hormone-receptor-Mechanism-of-activation-and-clinical-implications.pdf

  4. Ng FM et al. (2011). Impact of AOD-9604 on Glucose Homeostasis. Diabetes, Obesity & Metabolism.
    https://jofem.org/index.php/jofem/article/view/157

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