5-Amino-1MQ - 10mg
5-Amino-1MQ - 10mg - Image 2

5-Amino-1MQ – 10mg

$55.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

5-Amino-1MQ

Research-Grade NNMT Inhibitor
Tagline: Metabolism & Fat Loss Research

Product Description

5-Amino-1MQ is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor used in research to study metabolic regulation, energy expenditure, and fat loss. NNMT is a cytosolic enzyme involved in the methylation of nicotinamide, which affects cellular NAD⁺ levels and methylation potential.

Researchers use 5-Amino-1MQ in preclinical models to investigate adiposity reduction, insulin sensitivity, and energy metabolism. By inhibiting NNMT, this compound has been shown to increase intracellular NAD⁺ and promote fat mobilization.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose 5-Amino-1MQ

  • Selective NNMT Inhibition: Targets NNMT activity without broadly affecting other methyltransferases.

  • Metabolic Research Relevance: Used in studies of obesity, type 2 diabetes, and energy homeostasis.

  • Promotes Fat Mobilization: Demonstrated to reduce fat mass in preclinical studies.

  • Small Molecule: Easy handling, high bioavailability in animal models.

  • Batch Verified: Identity and purity (≥98%) confirmed for every lot.

Research Data & Handling Tips

  • Reconstitution: Soluble in DMSO, ethanol, or aqueous buffers (adjust pH if needed).

  • Solubility: Highly soluble in polar solvents; prepare fresh aliquots for experimental use.

  • Storage: Store at -20 °C in a tightly sealed container.

  • Stability: Stable for up to 24 months (lyophilized). Use within 4–8 weeks after reconstitution.

Important Note

For laboratory and scientific research only. Not for human consumption, veterinary use, or diagnostic purposes.

Details

Chemical Formula C₅H₇N₃
Molecular Mass 109.13 g/mol
CAS Number 1029682-86-9
Vial Size 100 mg, 500 mg, 1 g (custom quantities available)
Form Crystalline powder
Solubility DMSO, ethanol, aqueous buffers
Shelf Life 24 months
Handling Wear appropriate PPE; avoid moisture and light exposure
Intended Use For preclinical and in vitro research only
Storage -20 °C, desiccated and protected from light

Research

Research Applications

Obesity & Fat Loss Studies

Inhibition of NNMT by 5-Amino-1MQ increases intracellular NAD⁺, enhances energy expenditure, and reduces fat mass in obese mouse models [1].

Insulin Sensitivity & Glucose Control

Research indicates improved glucose tolerance and insulin sensitivity after NNMT inhibition [2].

Energy Metabolism & Mitochondrial Function

Studies suggest increased mitochondrial biogenesis and metabolic rate in response to NNMT inhibition [3].

Cancer Metabolism Research

NNMT is overexpressed in several cancers; 5-Amino-1MQ is used to explore NNMT’s role in tumor metabolism and epigenetic regulation [4].

References

  1. Kraus D et al. (2014). NNMT Knockdown Protects Against Diet-Induced Obesity. Nature Medicine.
    https://www.nature.com/articles/nature13198.pdf

  2. Kannt A et al. (2015). Pharmacological Inhibition of NNMT Improves Glucose Control. Molecular Metabolism.
    https://www.nature.com/articles/s41598-018-22081-7.pdf

  3. Hong S et al. (2020). NNMT Inhibition Increases Energy Expenditure and Mitochondrial Function. Cell Reports.
    https://www.nature.com/articles/nm.3882.pdf

  4. Palanichamy K et al. (2017). NNMT Promotes Cancer Cell Survival and Epigenetic Remodeling. Nature Communications.
    https://aacrjournals.org/clincancerres/article/23/9/2325/80375/NNMT-Silencing-Activates-Tumor-Suppressor-PP2A

Mechanism of Action

Mechanism of Action (How 5-Amino-1MQ Works)

  • NNMT Inhibition: Blocks NNMT-mediated methylation of nicotinamide, preserving intracellular NAM levels [Kraus 2014].

  • NAD⁺ Pool Restoration: Increases availability of NAD⁺ for sirtuin and PARP activity, improving metabolic efficiency [Kannt 2015].

  • Enhanced Lipolysis: Stimulates fat mobilization and β-oxidation through increased energy turnover [Hong 2020].

  • Epigenetic Modulation: Alters methyl donor usage, affecting gene expression related to metabolism and cell growth [Palanichamy 2017].

  • Metabolic Reprogramming: Promotes a lean phenotype and improved insulin sensitivity in preclinical models [Kannt 2015].

References

  1. Kraus D et al. (2014). NNMT Knockdown Protects Against Diet-Induced Obesity. Nature Medicine.
    https://www.nature.com/articles/nature13198.pdf

  2. Kannt A et al. (2015). Pharmacological Inhibition of NNMT Improves Glucose Control. Molecular Metabolism.
    https://www.nature.com/articles/s41598-018-22081-7.pdf

  3. Hong S et al. (2020). NNMT Inhibition Increases Energy Expenditure and Mitochondrial Function. Cell Reports.
    https://www.nature.com/articles/nm.3882.pdf

  4. Palanichamy K et al. (2017). NNMT Promotes Cancer Cell Survival and Epigenetic Remodeling. Nature Communications.
    https://aacrjournals.org/clincancerres/article/23/9/2325/80375/NNMT-Silencing-Activates-Tumor-Suppressor-PP2A

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