Description
What is 5-AMINO 1MQ?
5‑Amino‑1MQ, a compact methylquinolinium derivative, functions as a potent inhibitor of nicotinamide N‑methyltransferase (NNMT), an enzyme closely linked to metabolic regulation. With promising effects in preclinical studies—such as accelerated fat loss, enhanced glucose clearance, and improved muscle repair—this compound is rapidly emerging as a focus of metabolic and regenerative research. Its membrane‑permeable structure enables efficient cellular uptake, making 5‑Amino‑1MQ an exciting candidate for next‑generation therapeutic exploration.
Key Details
| Property |
Details |
| Chemical Formula |
C13H19N5 |
| Molecular Mass |
245.33 g/mol |
| CAS Number |
1029712-69-5 |
| Form |
Oral Capsule |
| Tablet Strength |
50 mg/capsule |
| Quantity per Bottle |
60 Capsules |
Details
Intended Use: 5-AMINO 1MQ capsules are designed for Research Purposes.
Storage: Store in a cool, dry place away from direct sunlight and moisture.
Dosage Form: 5-AMINO 1MQ is provided in pill form.
Shelf Life: The pills have a shelf life of 24 months when stored properly.
Research
Inhibits Obesity in Mice
In mice fed a high-fat diet, 5-Amino-1MQ lowered body weight by about 5 %, reduced belly fat by roughly 35 %, and shrank fat cell size by over 30 %. It also cut cholesterol by about 30 %, all without reducing how much the mice ate.
Microbiome Reset with Diet
When paired with a low-fat diet, 5-Amino-1MQ helped obese mice regain a body composition closer to lean animals. It also shifted gut bacteria, increasing beneficial Lactobacillus and reducing harmful Erysipelatoclostridium, in ways that diet alone did not achieve.
Boosts Strength and Endurance
Older mice given 5-Amino-1MQ showed grip strength gains of about 40 %, greater than with exercise alone. Combining the compound with exercise produced around 60 % improvements, along with longer-lasting boosts in endurance, suggesting powerful combined benefits for muscle health.
Mechanism of Action
5-Amino-1MQ works by inhibiting nicotinamide N-methyltransferase (NNMT), an enzyme that breaks down nicotinamide and reduces NAD⁺ levels. Blocking NNMT preserves NAD⁺, improving cellular energy metabolism, enhancing mitochondrial function, and promoting healthier fat cell activity, which can lead to better metabolic efficiency and reduced fat accumulation.
