Description
N-Acetyl Selank (10 mg)
Research-Grade Modified Heptapeptide
Tagline: Anxiolytic & Cognitive Research Innovation
Product Description
N-Acetyl Selank is an acetylated analog of Selank, a synthetic heptapeptide derived from the natural immunomodulatory sequence tuftsin. The N-acetyl modification increases peptide stability, resistance to enzymatic degradation, and blood-brain barrier permeability, making it a preferred compound for neurobehavioral and cognitive research.
Researchers study N-Acetyl Selank for its effects on GABAergic modulation, neurotransmitter regulation, BDNF expression, and stress resilience, providing a valuable model for anxiolytic, nootropic, and neuroprotective investigations.
For Laboratory and Scientific Research Use Only. Not for Human Consumption.
Why Researchers Choose N-Acetyl Selank
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Enhanced Stability: N-acetylation prolongs activity and bioavailability.
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GABAergic Modulation: Regulates GABA receptor and gene expression.
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Cognitive Research Use: Shown to enhance memory and focus in animal models.
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Stress & Anxiety Studies: Reduces stress-induced behavioral changes and normalizes neurotransmitter balance.
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High Purity: ≥98 % verified by HPLC and mass spectrometry.
Research Data & Handling Tips
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Formulation: Lyophilized peptide powder for reconstitution.
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Solubility: Soluble in sterile water or bacteriostatic water.
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Storage: Store lyophilized peptide at –20 °C; refrigerate (2–8 °C) after reconstitution.
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Stability: 24 months (lyophilized); use within 4-8 weeks after reconstitution.
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Handling: Protect from light; avoid repeated freeze–thaw cycles.
Important Note
For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.
Research
Research Applications
Anxiety & Stress Modulation
N-Acetyl Selank demonstrates anxiolytic properties without sedative effects in animal models, believed to act through modulation of GABA receptor expression and reduction of stress-induced gene activation [Filatova 2017].
Cognitive Enhancement & Memory
Studies indicate that Selank analogs enhance BDNF expression in hippocampal neurons, supporting memory formation and learning processes. The acetylated form provides longer activity and improved CNS penetration [Inozemtseva 2008].
Immune & Neuro-Immune Research
As a derivative of tuftsin, N-Acetyl Selank influences cytokine signaling and balances pro- and anti-inflammatory markers in stress-related immune dysregulation models [Volkova 2016].
Neuroprotection & Stress Resilience
Preclinical data show protection of neural tissue against oxidative damage and normalization of neurotransmitter levels (serotonin, dopamine) during chronic stress [Ashmarin 2005].
References
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Filatova E, et al. (2017). GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Frontiers in Pharmacology.
https://www.frontiersin.org/articles/10.3389/fphar.2017.00089/full
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Inozemtseva LS, et al. (2008). Intranasal Administration of the Peptide Selank Regulates BDNF Expression in the Rat Hippocampus in vivo. Doklady Biological Sciences.
https://pubmed.ncbi.nlm.nih.gov/18806861
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Volkova A, et al. (2016). Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in Pharmacology.
https://www.frontiersin.org/articles/10.3389/fphar.2016.00031/full
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Ashmarin IP, et al. (2005). Peptidergic Regulation of Brain Functions: Lessons from ACTH Analogues. Neuroscience and Behavioral Physiology.
https://link.springer.com/article/10.1007/s11055-005-0078-3
