Semax - 10mg
Semax - 10mg - Image 2

Semax – 10mg

$35.00

All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.

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Description

Semax (ACTH(4-10) Analog)

Research-Grade Nootropic Peptide
Tagline: Neuroprotection & Cognitive Research

Product Description

Semax is a synthetic analogue of the adrenocorticotropic hormone fragment ACTH(4-10), engineered for enhanced stability and prolonged action. It has been extensively studied in Russia and Eastern Europe for its neuroprotective, neurotrophic, and cognitive-modulating properties in preclinical and clinical settings.

Researchers use Semax to explore BDNF regulation, dopaminergic and serotonergic activity, neuroplasticity, and recovery after ischemic injury. Its ability to cross the blood-brain barrier makes it a powerful tool for studying brain health, learning, and memory mechanisms.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose Semax

  • Stable ACTH Fragment: Modified for enhanced resistance to enzymatic degradation.

  • Neurotrophic Effects: Increases BDNF and other neurotrophin expression in research models.

  • Broad Research Applications: Used for cognition, stroke recovery, and neuroinflammation studies.

  • No Significant Endocrine Effects: Does not stimulate cortisol release like full ACTH.

  • Batch Verified: Purity (≥98%) and identity confirmed for every lot.

Research Data & Handling Tips

  • Reconstitution: Dissolve in sterile water or saline; swirl gently until fully dissolved.

  • Solubility: Fully soluble in aqueous solutions.

  • Storage: Store lyophilized peptide at -20 °C. After reconstitution, aliquot and store at -80 °C.

  • Stability: Stable for 24 months (lyophilized); use within 4–8 weeks after reconstitution.

Important Note

For laboratory and scientific research only. Not for human consumption, veterinary use, or diagnostic purposes.

Details

Chemical Formula C₃₇H₅₁N₉O₁₀S
Molecular Mass ~753.9 Da
CAS Number 80714-61-0
Vial Size 1 mg, 5 mg, 10 mg
Form Lyophilized peptide powder
Solubility Water, PBS, or compatible buffer
Shelf Life 24 months (lyophilized)
Handling Protect from light and moisture; avoid repeated freeze-thaw cycles
Intended Use For preclinical and in vitro research only
Storage -20 °C (dry powder), -80 °C (after reconstitution)

Research

Research Applications

Neuroprotection & Ischemia Recovery

Semax has been shown to reduce neuronal damage, improve cerebral blood flow, and support recovery after ischemic injury in animal models [1].

Cognition & Memory Studies

Research indicates increased BDNF expression and improved learning and memory performance in rodent studies [2].

Anti-inflammatory & Neuroprotective Pathways

Preclinical studies of peptide compounds such as Semax suggest genomic regulation of genes involved in neurodegenerative and inflammatory pathways [3].

Mood & Stress Response Research

Modulates dopaminergic and serotonergic systems, providing insight into mood and stress regulation [4].

References

  1. Povarnina, P. Y., et al. (2020). Semax improves cerebral blood flow and protects against ischemia-induced damage. Neuropeptides, 83, 102114. https://doi.org/10.1016/j.npep.2020.102114

  2. Andreeva LA et al. (2002). Effects of Semax on BDNF Expression and Cognitive Function. Neuroscience Letters.
    https://link.springer.com/content/pdf/10.1023/A%3A1025177812262.pdf

  3. Shadrina, M. I., et al. (2014). Genomic effects of Semax on genes linked to neurodegenerative pathways. BMC Genomics, 15, 228.
    https://doi.org/10.1186/1471-2164-15-228

  4. Kubatiev AA et al. (2005). Influence of Semax on Dopamine and Serotonin Metabolism. Neuroscience & Behavioral Physiology.
    https://link.springer.com/article/10.1007/s11064-005-8826-8

Mechanism of Action

Mechanism of Action (How Semax Works)
  • ACTH(4-10) Receptor Interaction: Binds to melanocortin receptors, triggering neurotrophic and neuroprotective pathways [Ashmarin 1998].

  • BDNF Upregulation: Increases expression of brain-derived neurotrophic factor, supporting synaptic plasticity and neuronal survival [Andreeva 2002].

  • Anti-Inflammatory Modulation: Reduces NF-κB activation and pro-inflammatory cytokines (TNF-α, IL-1β) [Andreeva 2010].

  • Antioxidant Effect: Lowers oxidative stress markers and supports cellular defense mechanisms [Andreeva 2010].

  • Neurotransmitter Balance: Modulates dopamine and serotonin turnover, influencing mood and cognitive function [Kubatiev 2005].

References

  1. Povarnina, P. Y., et al. (2020). Semax improves cerebral blood flow and protects against ischemia-induced damage. Neuropeptides, 83, 102114. https://doi.org/10.1016/j.npep.2020.102114

  2. Andreeva LA et al. (2002). Effects of Semax on BDNF Expression and Cognitive Function. Neuroscience Letters.
    https://link.springer.com/content/pdf/10.1023/A%3A1025177812262.pdf

  3. Shadrina, M. I., et al. (2014). Genomic effects of Semax on genes linked to neurodegenerative pathways. BMC Genomics, 15, 228.
    https://doi.org/10.1186/1471-2164-15-228

  4. Kubatiev AA et al. (2005). Influence of Semax on Dopamine and Serotonin Metabolism. Neuroscience & Behavioral Physiology.
    https://link.springer.com/article/10.1007/s11064-005-8826-8

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